Personalized prognostic tools and gene-based therapies may improve the survival and quality of life of patients suffering from glioblastoma, an aggressive and deadly form of brain cancer
, reports a new University of Illinois study funded by the NIH National Cancer Institute.
"We confirmed known biomarkers of glioblastoma survival and discovered new general and clinical-dependent gene profiles," said Nicola Serao, a U of I Ph.D. candidate in animal sciences with a focus in statistical genomics. "We were able to compare biomarkers across three glioblastoma phases that helped us gain insight into the roles of genes associated with cancer survival."
Glioblastoma is a complex, multifactorial disease that has swift and devastating consequences, Serao said. Although some genes have been associated with the presence of glioblastoma, few have been identified as prognostic biomarkers of glioblastoma survival and fewer have been confirmed in independent reports.
"You can't just find one gene that is related to this cancer and fix it," he said. "This is one of the aspects of our research that makes it unique. We were able to look at several genes at the same time and relate our findings to this cancer."
Using genomic information from more than 22,000 genes, Serao took this huge piece of information and began slicing away at it, one gene at a time, until he ended up with a group of genes related to brain cancer.
He studied different survival variables, including length of survival from birth to death, from diagnosis to death, and from diagnosis to progression of the cancer.
"We studied different variables, but they were complementary, and allowed us to learn more about those genes," he said. "We understand that some genes have much more impact in cancer than others. And we also discovered that some genes only appeared in one variable, so they were specific for a given phase...