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14 Dec 2011 12:35 PM

Treating Skin Infections - AgaDerm, An Alternative To Bacitracin And Neomycin

Overuse of antibiotics has contributed towards drug-resistant bacteria emerging and spreading. Antibiotics have frequently been accused for so-called "superbugs" spreading. In the United States, virulent strains of MRSA (methicillin-resistant Staphylococcus aureus), a leading cause of community-acquired soft tissue and skin infections, are of paramount public health concern, due to the accelerated expansion of the highly drug-resistant strains, such as MRSA-USA300.

At present, large health organization's as well as government bodies recognize the urgent need for novel generations of antimicrobial agents. For these novel drugs to be effective they must be fast-acting, effective against drug-resistant bacteria, and minimize the probability of bacteria resistance.

Recent Investigation Associates Indiscriminant Use With topical Antibiotics to MRSA-USA300 Spread

According to an investigation published in Emerging Infectious Diseases, researchers from Japan revealed data indicating a role for over-the-counter (OTC) topical antibiotic ointments, which are prevalently used in the United States in helping MRSA-USA300 spread. Often, bacitracin and neomycin (active drugs) are contained in triple-antibiotic ointments, such as Neosporin. The investigation, which examined over 250 clinical isolates of MRSA from Korea and Japan, discovered that although the drug combination was effective against several MRSA strains, it was primarily ineffective against the virulent MRSA-USA300 strains.

Based on the association between the use of OTC medications and the prevalence of MRSA-USA300 in Korea and Japan (of which both are generally low in comparison to the U.S.), the researchers concluded that the selective pressure applied by indiscriminate use of OTC antibiotics may be partially accountable for the fast expansion of MRSA-USA300.

AgaDerm Proven Effective Against All MRSA Strains in a Phase 2 Clinical Trial

AgaDerm (NVC-422 Gel), designed by NovaBay Pharmaceuticals, Inc., represents a novel class of topical anti-infectives known as Aganocides®. The gel is designed to mirror the human body's natural defense system against fighting infection. Via a differentiated mechanism of action,...
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