It is widely recognized that overuse of antibiotics
has played a profound role in the emergence and dissemination of drug-resistant bacteria, and has often been blamed for the spread of these so-called "superbugs". In the U.S., virulent strains of MRSA (methicillin-resistant Staphylococcus aureus), a predominant cause of community-acquired skin and soft tissue infections, are of urgent public health concern given the rapid spread of highly drug-resistant strains, such as MRSA-USA300.
Government bodies and other large health organizations are now formally recognizing the urgent need for new generations of antimicrobial agents that are fast-acting and effective against drug-resistant bacteria. In order to be effective, these new drugs must minimize the possibility that bacteria could develop resistance.
Recent Study Links Indiscriminant Use of topical Antibiotics to Spread of MRSA-USA300
In a study published in Emerging Infectious Diseases, scientists from Japan reported data suggesting a role for over-the-counter (OTC) topical antibiotic ointments, which are used frequently in the U.S., in aiding the spread of MRSA-USA300. Triple-antibiotic ointments such as Neosporin often contain the active drugs bacitracin and neomycin. The study, which analyzed greater than 250 clinical isolates of MRSA from Japan and Korea, found that while this drug combination was effective against many strains of MRSA, the drugs were shown to be largely ineffective against the virulent MRSA-USA300 strains.
Based upon the relationship between the prevalence of MRSA-USA300 in Japan and Korea and the usage of OTC drugs (both of which are relatively low compared to the U.S.), the study concluded that the selective pressure applied by indiscriminant use of OTC antibiotics could be responsible (at least in part) for the rapid dissemination of MRSA-USA300.
AgaDerm Proven Effective Against All MRSA Strains in a Phase 2 Clinical Study
AgaDerm (NVC-422 Gel) represents a new class of topical anti-infectives known as Aganocides®, which were designed by NovaBay...